Cycling the Synapse Scenic versus Direct Routes for Vesicles

MinireviewCycling the Synapse : Scenic versus Direct Routes for Vesicles

siently connects the vesicle interior to the extracellular What happens to synaptic vesicles after they release space. Once the pore closes, the empty vesicle either their neurotransmitter content? Recent work on a varidetaches from the active zone or it remains in place and ety of synaptic systems shows that there is no single refills with neurotransmitter for another round of release answer t...

Arf6 regulates the cycling and the readily releasable pool of synaptic vesicles at hippocampal synapse

Recycling of synaptic vesicles (SVs) is a fundamental step in the process of neurotransmission. Endocytosed SV can travel directly into the recycling pool or recycle through endosomes but little is known about the molecular actors regulating the switch between these SV recycling routes. ADP ribosylation factor 6 (Arf6) is a small GTPase known to participate in constitutive trafficking between p...

Pharmacology Meets Vesicular Trafficking at a Cns Synapse: Pregabalin Effects on Synaptic Vesicle Cycling in Hippocampal Neurons

Synaptic vesicle cycling is not impaired in a glutamatergic and a cholinergic synapse that exhibit deficits in acidification and filling

The purpose of the present work was to investigate synaptic vesicle trafficking when vesicles exhibit alterations in filling and acidification in two different synapses: a cholinergic frog neuromuscular junction and a glutamatergic ribbon-type nerve terminal in the retina. These synapses display remarkable structural and functional differences, and the mechanisms regulating synaptic vesicle cyc...

Continuous and transient vesicle cycling at a ribbon synapse.

Optical methods were used to study the Ca2+ dependence of vesicle cycling in bipolar cells isolated from goldfish retinas. Uniformly raising the Ca2+ concentration to between 0.8 and 20 microM produced a continuous vesicle cycle of balanced exocytosis and endocytosis with a maximum rate equivalent to the turnover of the entire surface membrane of a terminal every 2 min (or approximately 900 ves...